Vortrag

Name:	Prof. Dr. Raymond Kaempfer
	Hebrew University of Jerusalem, School of Medicine, IMRIC Biochemistry and Molecular Biology, Israel
	Homepage (externer Link)
Termin/Ort:	Montag, 04.12.2017 16:00 Uhr im Gebäude 28 / Pfälzer Platz, Raum 027
Thema:	Control of mRNA splicing by noncoding intragenic RNA elements that evoke a celluar stress response.

Abstract:
We define structure and function of novel noncoding RNA elements within the tumor necrosis factor and hemoglobin genes that by activating a cellular stress response hitherto thought only to repress translation, render splicing of their mRNAs highly efficient. These RNA elements activate the RNA-dependent kinase, PKR. PKR-mediated mRNA splicing, we show, depends strictly on phosphorylation of translation initiation factor eIF2α which is both necessary and sufficient to achieve efficient splicing, while leaving translation intact.

References:
Cell Research (http://rdcu.be/qB2k)
Cell Reports (http://dx.doi.org/10.1016/j.celrep.2017.06.035 ).

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