Talk
| Name: | Prof. Dr. Raymond Kaempfer |
| Hebrew University of Jerusalem, School of Medicine, IMRIC Biochemistry and Molecular Biology, Israel | |
| Homepage (externer Link) | |
| Date/Location: | Monday, December 04st 2017 16:00 Uhr in Building 28 / Pfälzer Platz, Room 027 |
| Title: | Conrol of mRNA splicing by noncoding intragenic RNA elements that evoke a cellular stress response |
Abstract:
We define structure and function of novel noncoding RNA elements within the tumor necrosis factor and hemoglobin genes that by activating a cellular stress response hitherto thought only to repress translation, render splicing of their mRNAs highly efficient. These RNA elements activate the RNA-dependent kinase, PKR. PKR-mediated mRNA splicing, we show, depends strictly on phosphorylation of translation initiation factor eIF2α which is both necessary and sufficient to achieve efficient splicing,while leaving translation intact.
References:
Cell Research (http://rdcu.be/qB2k)
Cell Reports (http://dx.doi.org/10.1016/j.celrep.2017.06.035 ).
Interested people are welcome!