Prof. Dr. Fred Schaper

2023

Begutachteter Zeitschriftenartikel

Non-canonical STAT3 function reduces REDD1 transcription

Köhler, Nadine; Wundrack, Nicole; Schulz, Svenja; Bartonitz, Florian; Schaper, Fred; Dittrich, Anna

In: The FEBS journal / Vereinigung der Europäischen Biochemischen Gesellschaften - Oxford [u.a.] : Wiley-Blackwell, Bd. 290 (2023), Heft 7, S. 1765-1781

2022

Buchbeitrag

Prinzipien zellulärer Kommunikation

Müller-Newen, Gerhard; Heinrich, Peter C.; Hermanns, Heike M.; Schaper, Fred

In: Löffler/Petrides Biochemie und Pathobiochemie , 10th ed. 2022. - Berlin, Heidelberg : Springer Berlin Heidelberg ; Heinrich, Peter C., S. 513-526

Rezeptoren und ihre Signaltransduktion

Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

In: Löffler/Petrides Biochemie und Pathobiochemie , 10th ed. 2022. - Berlin, Heidelberg : Springer Berlin Heidelberg ; Heinrich, Peter C., S. 533-571

Mediatoren

Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

In: Löffler/Petrides Biochemie und Pathobiochemie , 10th ed. 2022. - Berlin, Heidelberg : Springer Berlin Heidelberg ; Heinrich, Peter C., S. 527-532

Begutachteter Zeitschriftenartikel

Decoding cellular communication - an information theoretic perspective on cytokine and endocrine signaling

Schaper, Fred; Jetka, Tomasz; Dittrich, Anna

In: Current opinion in endocrine and metabolic research - Amsterdam : Elsevier . - 2022

All-in-one superparamagnetic and SERS-active niosomes for dual-targeted in vitro detection of breast cancer cells

Maurer, Viktor; Zarinwall, Ajmal; Wang, Zunhao; Wundrack, Stefan; Wundrack, Nicole; Ag Seleci, Didem; Helm, Vivien; Otenko, Daniil; Frank, Claudia; Schaper, Fred; Stosch, Rainer; Garnweitner, Georg

In: Sensors & Diagnostics / Royal Society of Chemistry - London : RSC Publishing . - 2022, insges. 16 S.

2021

Begutachteter Zeitschriftenartikel

Glucocorticoids attenuate interleukin6induced cFos and Egr1 expression and impair neuritogenesis in PC12 cells

Bongartz, Hannes; Seiß, Elena Anne; Bock, Jörg; Schaper, Fred

In: Journal of neurochemistry - Oxford: Wiley-Blackwell, Bd. 157 (2021), 3, S. 532-549

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

Fiebelkow, Jessica; Guendel, André; Guendel, Beate; Mehwald, Nora; Jetka, Tomasz; Komorowski, Michal; Waldherr, Steffen; Schaper, Fred; Dittrich, Anna

In: Cell communication and signaling - London: Biomed Central, Bd. 19 (2021), 1, insges. 19 S.

2019

Begutachteter Zeitschriftenartikel

Intragenic regulation of SOCS3 isoforms

Klepsch, Oliver; Namer, Lise Sarah; Köhler, Nadine; Kaempfer, Raymond; Dittrich, Anna; Schaper, Fred

In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), 1, Artikel 70, insgesamt 15 Seiten

Designing optimal experiments to discriminate interaction graph models

Thiele, Sven; Heise, Sandra; Hessenkemper, Wiebke; Bongartz, Hannes; Fensky, Melissa; Schaper, Fred; Klamt, Steffen

In: IEEE ACM transactions on computational biology and bioinformatics - New York, NY: IEEE, Bd. 16 (2019), 3, S. 925-935

Robustness and information transfer within IL-6-induced JAK/STAT signalling

Billing, Ulrike; Jetka, Tomasz; Nortmann, Lukas; Wundrack, Nicole; Komorowski, Michal; Waldherr, Steffen; Schaper, Fred; Dittrich, Anna

In: Communications biology - London: Springer Nature, Vol. 2.2019, Art. 27, insgesamt 14 S.

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression - fusing experimental insights and dynamic modelling

Reeh, Heike; Rudolph, Nadine; Billing, Ulrike; Christen, Henrike; Streif, Stefan; Bullinger, Eric; Schliemann-Bullinger, Monica; Findeisen, Rolf; Schaper, Fred; Huber, Heinrich; Dittrich, Anna

In: Cell communication and signaling - London: Biomed Central, Vol. 17.2019, 1, Art. 17:46, insgesamt 21 Seiten

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

Bongartz, Hannes; Gille, Karen; Hessenkemper, Wiebke; Mandel, Katharina; Lewitzky, Marc; Feller, Stephan M.; Schaper, Fred

In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), Article 135, insgesamt 23 Seiten

2018

Begutachteter Zeitschriftenartikel

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability

Williams, Jamie J. L.; Alotaiq, Nasser; Mullen, William; Burchmore, Richard; Liu, Libin; Baillie, George S.; Schaper, Fred; Pilch, Paul F.; Palmer, Timothy M.

In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Vol. 9.2018, 1, Art. 168, insgesamt 17 S.

2017

Begutachteter Zeitschriftenartikel

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells

Bongartz, Hannes; Heßenkemper, Wiebke; Müller, Christian; Fensky, Melissa; Fritsch, Johannes; Mandel, Katharina; Behrmann, Iris; Haan, Claude; Fischer, Thomas; Feller, Stephan M.; Schaper, Fred

In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 35 (2017), S. 37-47

2016

Begutachteter Zeitschriftenartikel

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-Inhibitor REDD1 in a STAT3-dependent manner

Pinno, Jessica; Bongartz, Hannes; Klepsch, Oliver; Wundrack, Nicole; Poli, Valeria; Schaper, Fred; Dittrich, Anna

In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, 1989, Bd. 28.2016, 8, S. 907-916

2015

Begutachteter Zeitschriftenartikel

Interleukin-6: Biology, signaling and strategies of blockade

Schaper, Fred; Rose-John, Stefan

In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 475-487

"Family reunion" - a structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines

Rose-John, Stefan; Scheller, Jürgen; Schaper, Fred

In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 471-474

A two-level approach for fusing early signaling events and long term cellular responses

Rudolph, Nadine; Meyer, Tina; Franzen, Kristina; Garbers, Christoph; Schaper, Fred; Streif, Stefan; Dittrich, Anna; Findeisen, Rolf

In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, 2015, Bd. 48.2015, 8, S. 1228-1233[Kongress: 9th IFAC Symposium on Advanced Control of Chemical Processes ADCHEM 2015, Whistler, Canada, 7-10 June, 2015]

Systems biology of IL-6, IL-12 family cytokines

Dittrich, Anna; Hessenkemper, Wiebke; Schaper, Fred

In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 595-602

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch

Wolf, Alexandra; Eulenfeld, René; Bongartz, Hannes; Hessenkemper, Wiebke; Simister, Philip C.; Lievens, Sam; Tavernier, Jan; Feller, Stephan M.; Schaper, Fred

In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, 1989, Bd. 27.2014, 2, S. 340-352, 2015

2014

Buchbeitrag

Prinzipien zellulärer Kommunikation

Müller-Newen, Gerhard; Heinrich, Peter C.; Hermanns, Heike M.; Schaper, Fred

In: Löffler/Petrides Biochemie und Pathobiochemie , 9., vollständig überarbeitete Auflage - Berlin : Springer ; Heinrich, Peter C. *1939-* . - 2014, S. 395-406

Rezeptoren und ihre Signaltransduktion

Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

In: Löffler/Petrides Biochemie und Pathobiochemie , 9., vollständig überarbeitete Auflage - Berlin : Springer ; Heinrich, Peter C. *1939-* . - 2014, S. 411-441

Mediatoren

Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

In: Löffler/Petrides Biochemie und Pathobiochemie , 9., vollständig überarbeitete Auflage - Berlin : Springer ; Heinrich, Peter C. *1939-* . - 2014, S. 407-410

2013

Buchbeitrag

Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach

Dittrich, Anna; Siewert, Elmar; Schaper, Fred

In: JAK-STAT signalling: methods and protocols / ed. by Sandra E. Nicholson and Nicos A. Nicola: methods and protocols - New York [u.a.]: Humana Pr., 2013 . - 2013, S. 69-80 - (Methods in molecular biology; 967)

Begutachteter Zeitschriftenartikel

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

Thiem, Stefan; Pierce, Thomas P.; Palmieri, Michelle; Putoczki, Tracy L.; Buchert, Michael; Preaudet, Adele; Farid, Ryan O.; Love, Chris; Catimel, Bruno; Lei, Zhengdeng; Rozen, Steve; Gopalakrishnan, Veena; Schaper, Fred; Hallek, Michael; Boussioutas, Alex; Tan, Patrick; Jarnicki, Andrew; Ernst, Matthias

In: The journal of clinical investigation: JCI : the publication of the American Society for Clinical Investigation - Ann Arbor, Mich: ASCJ, 1924, Bd. 123.2013, 2, S. 767-781

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells

Wolf, Alexandra; Eulenfeld, René; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

In: JAK-STAT - London: Taylor & Francis Group, 2012, Bd. 2.2013, 3, insges. 13 S.

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domains point mutations associated with Noonan syndrome and leukemia

Müller, Pia J.; Rigboldt, Kristoffer G.; Paterok, Dirk; Piehler, Jacob; Vanselow, Jens; Lasonder, Edwin; Andersen, Jens S.; Schaper, Fred; Sobota, Radoslaw M.

In: Journal of proteomics - New York, NY [u.a.]: Elsevier, 2008, Bd. 84.2013, S. 132-147

JAK/STAT signalling - an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology

Blätke, Mary Ann; Dittrich, Anna; Rohr, Christian; Heiner, Monika; Schaper, Fred; Marwan, Wolfgang

In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, 2005, Bd. 9.2013, S. 1290-1307

2012

Buchbeitrag

JAK-STAT signalling as example for a database-supported modular modelling concept

Blätke, Mary Ann; Dittrich, Anna; Heiner, Monika; Schaper, Fred; Marwan, Wolfgang

In: Computational Methods in Systems Biology / Gilbert , David - Berlin, Heidelberg : Springer ; Gilbert, David . - 2012, S. 362-365 - (Lecture Notes in Bioinformatics; 7605) Kongress: CMSB 2012 10 London, UK 2012.10.03-05

Originalartikel in begutachteter internationaler Zeitschrift

Glucocorticoids increase interleukin-6 dependent gene induction by interfering with the expression of the SOCS 3 feedback inhibitor

Dittrich, Anna; Khouri, Christina; Sackett, Sara Dutton; Ehlting, Christian; Böhmer, Oliver; Albrecht, Ute; Bode, Johannes G.; Trautwein, Christian; Schaper, Fred

In: Hepatology. - Hoboken, NJ : Wiley Interscience, Bd. 55.2012, 1, S. 256-266

Hepatic acute phase proteins - regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kB-dependent signaling

Bode, Johannes G.; Albrecht, Ute; Häussinger, Dieter; Heinrich, Peter C.; Schaper, Fred

In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 496-505

Interleukin-6 signalling - more than Jaks and STATs

Eulenfeld, René; Dittrich, Anna; Khouri, Christina; Müller, Pia J.; Mütze, Barbara; Wolf, Alexandra; Schaper, Fred

In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 486-495

Plasticity and cross-talk of Interleukin 6-type cytokines

Garbers, Christoph; Hermanns, Heike M.; Schaper, Fred; Müller-Newen, Gerhard; Grötzinger, Joachim; Rose-John, Stefan; Scheller, Jürgen

In: Cytokine & growth factor reviews - Oxford [u.a.] : Elsevier, Bd. 23.2012, 3, S. 85-97

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling

Dittrich, Anna; Quaiser, Tom; Khouri, Christina; Görtz, Dieter; Mönnigmann, Martin; Schaper, Fred

In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, 8, S. 2119-2134, 2012

2011

Originalartikel in begutachteter internationaler Zeitschrift

Glucagon counteracts interleukin-6-dependent gene expression by redundant action of EPAC and PKA

Khouri, Christina; Dittrich, Anna; Sackett, Sara Dutton; Denecke, Bernd; Trautwein, Christian; Schaper, Fred

In: Biological chemistry - Berlin [u.a.]: de Gruyter, Bd. 392.2011, S. 1123-1134

Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini

Simister, Philip C.; Schaper, Fred; O'Reilly, Nicola; McGowan, Simon; Feller, Stephan M.

In: PLoS biology - Lawrence, KS: PLoS, Bd. 9.2011, 2

A simple work flow for biologically inspired model reduction - application to early JAK-STAT signaling

Quaiser, Tom; Dittrich, Anna; Schaper, Fred; Mönnigmann, Martin

In: BMC systems biology - London: BioMed Central, Bd. 5.2011, 30, insges. 30 S.

Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification

Ryll, Anke; Samaga, Regina; Schaper, Fred; Alexopoulos, Leonidas G.; Klamt, Steffen

In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7.2011, 12, S. 3253-3270

2010

Originalartikel in begutachteter internationaler Zeitschrift

Cross-regulation of cytokine signalling - pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation

Radtke, Simone; Wüller, Stefan; Yang, Xiang-ping; Lippok, Barbara E.; Mütze, Barbara; Mais, Christine; Schmitz-Van de Leur, Hildegard; Bode, Johannes G.; Gaestel, Matthias; Heinrich, Peter C.; Behrmann, Iris; Schaper, Fred; Hermanns, Heike M.

In: Journal of cell science . - Cambridge : Company of Biologists Limited, Bd. 123.2010, 6, S. 947-959

2009

Begutachteter Zeitschriftenartikel

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane

Eulenfeld, R.; Schaper, F.

In: J Cell Sci, Volume 122, Issue Pt 1, Pages: 55-64, 2009

Originalartikel in begutachteter internationaler Zeitschrift

Signal transduction in the footsteps of Goethe and Schiller

Friedrich, Karlheinz; Lindquist, Jonathan A.; Entschladen, Frank; Serfling, Edgar; Thiel, Gerald; Kieser, Arnd; Giehl, Klaudia; Ehrhardt, Christina; Feller, Stephan M.; Ullrich, Oliver; Schaper, Fred; Janssen, Ottmar Johannes; Hass, Ralf

In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 7.2009, Art. 2, insges. 6 S.

Signal transduction - receptors, mediators, and genes

Entschladen, Frank; Lindquist, Jonathan A.; Serfling, Edgar; Thiel, Gerald; Kieser, Arnd; Giehl, Klaudia; Ehrhardt, Christina; Feller, Stephan M.; Ullrich, Oliver; Schaper, Fred; Janssen, Ottmar Johannes; Hass, Ralf; Friedrich, Karlheinz

In: Science signaling - Washington, DC [u.a.] : Assoc., Bd. 2 (2009), Heft 63, insges. 4 S.

2008

Begutachteter Zeitschriftenartikel

SHPS-1/SIRP1alpha contributes to interleukin-6 signalling

Sobota, R. M.; Müller, P. J.; Khouri, C.; Ullrich, A.; Poli, V.; Noguchi, T.; Heinrich, P. C.; Schaper, F.

In: Cell Signal, Volume 20, Issue 7, Pages: 1385-91, 2008

Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation

Sobota, R. M.; Müller, P. J.; Heinrich, P. C.; Schaper, F.

In: Biochem J, Volume 412, Issue 1, Pages: 65-72, 2008

Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration

Clahsen, T.; Schaper, F.

In: J Leukoc Biol, Volume 84, Issue 6, Pages: 1521-9; 2008

2007

Begutachteter Zeitschriftenartikel

Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene

Albrecht, U.; Yang, X.; Asselta, R.; Keitel, V.; Tenchini, M. L.; Ludwig, S.; Heinrich, P. C.; Häussinger, D.; Schaper, F.; Bode, J. G.

In: Cell Signal, Volume 19, Issue 9, Pages: 1866-78, 2007

Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade

Ehlting, C.; Lai, W. S.; Schaper, F.; Brenndorfer, E. D.; Matthes, R. J.; Heinrich, P. C.; Ludwig, S.; Blackshear, P. J.; Gaestel, M.; Häussinger, D.; Bode, J. G.

In: J Immunol, Volume 178, Issue 5, Pages: 2813-26, 2007

2006

Begutachteter Zeitschriftenartikel

Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism

Stross, C.; Radtke, S.; Clahsen, T.; Gerlach, C.; Volkmer-Engert, R.; Schaper, F.; Heinrich, P. C.; Hermanns, H. M.

In: J Biol Chem, Volume 281, Issue 13, Pages: 8458-68, 2006

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes

Tron, K.; Samoylenko, A.; Musikowski, G.; Kobe, F.; Immenschuh, S.; Schaper, F.; Ramadori, G.; Kietzmann, T.

In: J Hepatol, Volume 45, Issue 1, Pages: 72-80, 2006

Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130

Lehmann, U.; Sommer, U.; Smyczek, T.; Hörtner, M.; Frisch, W.; Volkmer-Engert, R.; Heinrich, P. C.; Schaper, F.; Haan, S.

In: Cell Signal, Volume 18, Issue 1, Pages: 40-9, 2006

2005

Begutachteter Zeitschriftenartikel

The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling

Clahsen, T.; Lehmann, U.; Stross, C.; Hermanns, H. M.; Volkmer-Engert, R.; Schneider-Mergener, J.; Heinrich, P. C.; Schaper, F.

In: Cell Signal, Volume 17, Issue 5, Pages: 559-69, 2005

Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases

Sommer, U.; Schmid, C.; Sobota, R. M.; Lehmann, U.; Stevenson, N. J.; Johnston, J. A.; Schaper, F.; Heinrich, P. C.; Haan, S.

In: J Biol Chem, Volume 280, Issue 36, Pages: 31478-88, 2005

Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo

Yang, X. P.; Schaper, F.; Teubner, A.; Lammert, F.; Heinrich, P. C.; Matern, S.; Siewert, E.

In: J Hepatol, Volume 43, Issue 4, Pages: 704-10, 2005

2004

Begutachteter Zeitschriftenartikel

Interleukin-6 is a direct mediator of T cell migration

Weissenbach, M.; Clahsen, T.; Weber, C.; Spitzer, D.; Wirth, D.; Vestweber, D.; Heinrich, P. C.; Schaper, F.

In: Eur J Immunol, Volume 34, Issue 10, Pages: 2895-906, 2004

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

Fischer, P.; Lehmann, U.; Sobota, R. M.; Schmitz, J.; Niemand, C.; Linnemann, S.; Haan, S.; Behrmann, I.; Yoshimura, A.; Johnston, J. A.; Müller-Newen, G.; Heinrich, P. C.; Schaper, F.

In: Biochem J, Volume 378, Issue Pt 2, Pages: 449-60, 2004

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK

Zhao, L.; Hart, S.; Cheng, J.; Melenhorst, J. J.; Bierie, B.; Ernst, M.; Stewart, C.; Schaper, F.; Heinrich, P. C.; Ullrich, A.; Robinson, G. W.; Hennighausen, L.

In: J Biol Chem, Volume 279, Issue 42, Pages: 44093-100, 2004

Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression

Yang, X. P.; Albrecht, U.; Zakowski, V.; Sobota, R. M.; Häussinger, D.; Heinrich, P. C.; Ludwig, S.; Bode, J. G.; Schaper, F.

In: J Biol Chem, Volume 279, Issue 43, Pages: 45279-89, 2004

2003

Begutachteter Zeitschriftenartikel

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Niemand, C.; Nimmesgern, A.; Haan, S.; Fischer, P.; Schaper, F.; Rossaint, R.; Heinrich, P. C.; Müller-Newen, G.

In: J Immunol, Volume 170, Issue 6, Pages: 3263-72, 2003

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3

Bode, J. G.; Ludwig, S.; Ehrhardt, C.; Albrecht, U.; Erhardt, A.; Schaper, F.; Heinrich, P. C.; Häussinger, D.

In: Faseb J, Volume 17, Issue 3, Pages: 488-90, 2003

TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex

Bode, J. G.; Schweigart, J.; Kehrmann, J.; Ehlting, C.; Schaper, F.; Heinrich, P. C.; Häussinger, D.

In: J Immunol, Volume 171, Issue 1, Pages: 257-66, 2003

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

Lehmann, U.; Schmitz, J.; Weissenbach, M.; Sobota, R. M.; Hörtner, M.; Friederichs, K.; Behrmann, I.; Tsiaris, W.; Sasaki, A.; Schneider-Mergener, J.; Yoshimura, A.; Neel, B. G.; Heinrich, P. C.; Schaper, F.

In: J Biol Chem, Volume 278, Issue 1, Pages: 661-71, 2003

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

Heinrich, P. C.; Behrmann, I.; Haan, S.; Hermanns, H. M.; Müller-Newen, G.; Schaper, F.

In: Biochem J, Volume 374, Issue Pt 1, Pages: 1-20, 2003

Lehrbuch

Kapitel 28: Endokrine Funktionen II: Zytokine

Heinrich, P.C.; Schaper, F.; Timmermann, A.; Martens, A.; Lehmann, U.

In: in: Löffler, G., Petrides, P.E. (eds.): Biochemie und Pathobiochemie 7. Auflage. Springer-Verlag Berlin Heidelberg, 2003, pp. 813-835

2001

Begutachteter Zeitschriftenartikel

A completely foreign receptor can mediate an interferon-gamma-like response

Strobl, B.; Arulampalam, V.; Is'harc, H.; Newman, S. J.; Schlaak, J. F.; Watling, D.; Costa-Pereira, A. P.; Schaper, F.; Behrmann, I.; Sheehan, K. C.; Schreiber, R. D.; Horn, F.; Heinrich, P. C.; Kerr, I. M.

In: Embo J, Volume 20, Issue 19, Pages: 5431-42, 2001

Expression of suppressors of cytokine signaling during liver regeneration

Campbell, J. S.; Prichard, L.; Schaper, F.; Schmitz, J.; Stephenson-Famy, A.; Rosenfeld, M. E.; Argast, G. M.; Heinrich, P. C.; Fausto, N.

In: J Clin Invest, Volume 107, Issue 10, Pages: 1285-92, 2001

The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription

Bode, J. G.; Ludwig, S.; Freitas, C. A.; Schaper, F.; Ruhl, M.; Melmed, S.; Heinrich, P. C.; Häussinger, D.

In: Biol Chem, Volume 382, Issue 10, Pages: 1447-53, 2001

Termination and modulation of IL-6-type cytokine signaling

Heinrich, P. C.; Bode, J.; Decker, M.; Graeve, L.; Martens, A.; Müller-Newen, G.; Pflanz, S.; Schaper, F.; Schmitz, J.

In: Adv Exp Med Biol, Volume 495, Pages: 153-60, 2001

The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B

Bode, J. G.; Fischer, R.; Häussinger, D.; Graeve, L.; Heinrich, P. C.; Schaper, F.

In: J Immunol, Volume 167, Issue 3, Pages: 1469-1481, 2001

Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited

Friederichs, K.; Schmitz, J.; Weissenbach, M.; Heinrich, P. C.; Schaper, F.

In: Eur J Biochem, Volume 268, Issue 24, Pages: 6401-7, 2001

2000

Begutachteter Zeitschriftenartikel

The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction

Schmitz, J.; Dahmen, H.; Grimm, C.; Gendo, C.; Muller-Newen, G.; Heinrich, P. C.; Schaper, F.

In: Journal of Immunology 164, Issue 2, Pages: 848-54, 2000

Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA

Terstegen, L.; Maassen, B. G.; Radtke, S.; Behrmann, I.; Schaper, F.; Heinrich, P. C.; Graeve, L.; Gatsios, P.

In: FEBS Lett, Volume 478, Issue 1-2, Pages: 100-4, 2000

The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130

Terstegen, L.; Gatsios, P.; Bode, J. G.; Schaper, F.; Heinrich, P. C.; Graeve, L.

In: J Biol Chem, 275, Issue 25, Pages: 18810-17, 2000

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

Schmitz, J.; Weissenbach, M.; Haan, S.; Heinrich, P. C.; Schaper, F.

In: J Biol Chem, Volume 275, Issue 17, Pages: 12848-56, 2000

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

Rödel, B.; Tavassoli, K.; Karsunky, H.; Schmidt, T.; Bachmann, M.; Schaper, F.; Heinrich, P.; Shuai, K.; Elsässer, H. P.; Möröy, T.

In: Embo J, Volume 19, Issue 21, Pages: 5845-55, 2000

Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies

Müller-Newen, G.; Küster, A.; Wijdenes, J.; Schaper, F.; Heinrich, P. C.

In: J Biol Chem, Volume 275, Issue 7, Pages: 4579-86, 2000

Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor

Hermanns, H. M.; Radtke, S.; Schaper, F.; Heinrich, P. C.; Behrmann, I.

In: J Biol Chem, Volume 275, Issue 52, Pages: 40742-8, 2000

Cytoplasmic STAT proteins associate prior to activation

Haan, S.; Kortylewski, M.; Behrmann, I.; Müller-Esterl, W.; Heinrich, P. C.; Schaper, F.

In: Biochem J, Volume 345 Pt 3, Pages: 417-21, 2000

A new peptide-affinity tag for the detection and affinity purification of recombinant proteins with a monoclonal antibody

Böldicke, T.; Struck, F.; Schaper, F.; Tegge, W.; Sobek, H.; Villbrandt, B.; Lankenau, P.; Böcher, M.

In: J Immunol Methods, Volume 240, Issue 1-2, Pages: 165-83, 2000

Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation

Anhuf, D.; Weissenbach, M.; Schmitz, J.; Sobota, R.; Hermanns, H. M.; Radtke, S.; Linnemann, S.; Behrmann, I.; Heinrich, P. C.; Schaper, F.

In: J Immunol, Volume 165, Issue 5, Pages: 2535-43, 2000

1999

Begutachteter Zeitschriftenartikel

LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages

Bode, J.G.; Nimmesgern, A.; Schmitz, J.; Schaper, F.; Schmitt, M.; Frisch, W.; Häussinger, D.; Heinrich, P.C.; Graeve, L.

In: FEBS Letters 463 (3) , pp. 365-370, 1999

Different protein turnover of interleukin-6-type cytokine signalling components

Siewert, E.; Müller-Esterl, W.; Starr, R.; Heinrich, P.C.; Schaper, F.

In: European Journal of Biochemistry 265 (1) , pp. 251-257, 1999

Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.

Thiel, S.; Behrmann, I.; Timmermann, A.; Dahmen, H.; Müller-Newen, G.; Schaper, F.; Tavernier, J.; Pitard, V.; Heinrich, P.C.; Graeve, L.

In: Biochemical Journal 339 (1) , pp. 15-19, 1999

Characterization and binding specificity of the monomeric STAT3-SH2 domain

Haan, S.; Hemmann, U.; Hassiepen, U.; Schaper, F. Schneider-Mergener J.; Wollmer, A.; Heinrich, P.C.; Grötzinger, J.

In: Journal of Biological Chemistry 274 (3) , pp. 1342-1348, 1999

1998

Begutachteter Zeitschriftenartikel

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

Schaper, F.; Gendo, C.; Eck, M.; Schmitz, J.; Grimm, C.; Anhuf, D.; Kerr, I.M.; Heinrich, P.C.

In: Biochemical Journal 335 (3) , pp. 557-565, 1998

In vivo formation of IRF-1 homodimers

Kirchhoff, S.; Schaper, F.; Oumard, A.; Hauser, H.

In: Biochimie 80 (8-9) , pp. 659-664, 1998

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

Heinrich, P.C.; Behrmann, I.; Müller-Newen, G.; Schaper, F.; Graeve, L.

In: Biochemical J. 224 (2) , pp. 297-314, 1998

Functional domains of interferon regulatory factor 1 (IRF-1)

Schaper, F.; Kirchhoff, S.; Posern, G.; Köster, M.; Oumard, A.; Sharf, R.; Levi, B.-Z.; Hauser, H.

In: Biochemical Journal 335 (1) , pp. 147-157, 1998

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130

Thiel, S.; Dahmen, H.; Martens, A.; Müller-Newen, G.; Schaper, F.; Heinrich, P.C.; Graeve, L.

In: FEBS Letters 441 (2) , pp. 231-234, 1998

1997

Begutachteter Zeitschriftenartikel

Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA

Sharf, R.; Meraro, D.; Azriel, A.; Thornton, A.M.; Ozato, K.; Petricoin, E.F.; Larner, A.C.; Schaper, F.; Hauser, H.; Levi, B.-Z.

In: Journal of Biological Chemistry 272 (15) , pp. 9785-9792, 1997

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

Schaper, F.; Siewert, E.; Gómez-Lechón, M.J.; Gatsios, P.; Sachs, M.; Birchmeier, W.; Heinrich, P.C.; Castell, J.

In: FEBS Letters 405 (1) , pp. 99-103, 1997

1996

Begutachteter Zeitschriftenartikel

Regulation of cell growth by IRF-1 in BHK-21 cells

Kirchhoff, S.; Kröger, A.; Cruz, H.; Tümmler, M.; Schaper, F.; Köster, M.; Hauser, H.

In: Cytotechnology 22 (1-3) , pp. 147-156, 1996

1995

Begutachteter Zeitschriftenartikel

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR

Kirchhoff, S.; Koromilas, A.E.; Schaper, F.; Grashoff, M.; Sonenberg, N.; Hauser, H.

In: Oncogene 11 (3) , pp. 439-445, 1995

Proliferation control of mammalian cells by the tumor suppressor IRF-1

Köster, M.; Kirchhoff, S.; Schaper, F.; Hauser, H.

In: Cytotechnology 18 (1-2) , pp. 67-75, 1995

Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters

Kirchhoff, S.; Köster, M.; Wirth, M.; Schaper, F.; Gossen, M.; Bujard, H.; Hauser, H.

In: Trends in Genetics 11 , pp. 219-220, 1995

1994

Begutachteter Zeitschriftenartikel

A multifunctional vector family for gene expression in mammalian cells

Dirks, W.; Schaper, F.; Kirchhoff, S.; Morelle, C.; Hauser, H.

In: Gene 149 , pp. 387-388, 1994

A new hybrid promoter directs transcription at identical start points in mammalian cells and in vitro

Dirks, W.; Schaper, F.; Hauser, H.

In: Gene 149 , pp. 389-390, 1994

1993

Begutachteter Zeitschriftenartikel

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes

Kirchhoff, S.; Schaper, F.; Hauser, H.

In: Nucleic Acids Research 21 (12) , pp. 2881-2889, 1993

Letzte Änderung: 15.12.2023 - Ansprechpartner: Fred Schaper