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Talk

 

Name:      Dr. Michal Komorowski
  Polish Academy of Science
Institute of Fundamental Technological Research
  Homepage (external Link)
Date/Location: Tuesday, May 10th 2016, 5 pm,  Building 28 /  Room 27
Title:  Information flow in signalling pathways
Abstact: High throughput experimental approaches and the advances of computational capabilities continue to reshape modern biology. Thus, mathematical biology offers new possibilities for mathematicians and biologists to explore signal transduction, an important and highly complex aspect of cell biology. The molecular mechanisms how cells transduce biochemical signals are widely understood. Biochemical descriptions however failed to reveal how stimuli are translated into distinct responses. Signalling pathways are highly complex as they are functionally pleiotropic and biochemical reactions intrinsically stochastic. In the talk I will try to present how mathematical methods of information theory and probabilistic dynamical modelling can contribute to understanding of how information flows in signalling pathways.In particular, I will present developed analytical and computational tools required to improve our understanding how cellular signalling processes can derive a variety of distinct outputs from complex inputs. To overcome limitations of existing methods we have integrated advanced concepts of statistical inference with information theory and high content confocal imaging. The concepts have been applied to obtain new insights into mechanisms that govern dose dependent responses to type I interferons via STAT1 and STAT2 pathways as well as to TNF via NF-kB pathway.

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Talk

 

Name:      Prof. Dr. Karlheinz Friedrich
  Medical School University of Jena
Institute of Biochemistry II
  Homepage (external Link)
Date/Location: Wednesday, 09.03.2016 17:00 Building 16 /  Room 154
Title:  Thymic Stromal Lymphopoietin (TSLP) and its receptor: Signaling and medical aspects of an intriguing cytokine

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Talk

 

Name:      Dr. Mario Köster
  Helmholtz Zentrum für Infektionsforschung, Braunschweig
  Homepage (external link)
Date/Location: Thursday, 12.11.2015 17:00 Building  28 / Pfälzer Platz, Room 027
Title:  Dynamics of antiviral signalling

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Talk

 

Name:      Prof. Dr. Serge Haan
  Head of the Molecular Disease Mechanisms Group, Life Sciences Research Unit, University of Luxembourg
  Homepage (external link)
Date/Location: Thursday, 09.02.2015 17:00 Building  28 / Pfälzer Platz, Room 027
Title:  The Jak/STAT/SOCS pathway in gastrointestinal malignancies

Abstract: The Jak/STAT/SOCS pathway in gastrointestinal malignancies

Although the exact disease mechanisms are often not completely understood, the importance of Janus kinases, STAT factors and SOCS proteins in pathological processes is well established. In recent years, we were interested in the role of the Jak/STAT/SOCS signalling pathway in gastrointestinal diseases. One of our projects dealt with the potential role of SOCS proteins in colon cancer. By combining a meta-analysis with analyses of our own patient cohort we could identify SOCS2 and SOCS6 as potential biomarkers for colon cancer. Furthermore, we are interested in signalling mechanism initiated by mutated PDGFRa proteins. We are primarily interested in mutations occurring in the context of gastrointestinal stromal tumours (GIST) but we also extended our study to include an oncogenic fusion protein called FIP1L1-PDGFRa, which was identified in patients with chronic eosinophilic leukaemia. We found that the oncogenic mutants display skewed signalling properties if compared to the wild-type receptor. The observed unconventional signalling pattern includes the activation of STAT factors via a non-canonical activation mechanism.

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Talk

 

Name:      PD. Dr. Heike Hermanns
  Medizinische Klinik und Poliklinik II, Universität Würzburg
  Homepage (external link)
Date/Location: Thursday, 13.11.2014 17:00 Building  28 / Pfälzer Platz, Room 027
Title:  Receptor endocytosis as fine-tuning mechanism to regulate IL-6-mediated inflammatory responses

 

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Talk

 

Name:      Prof. Dr. Raymond Kaempfer
  Hebrew University of Jerusalem, School of Medicine, IMRIC Biochemistry and Molecular Biology, Israel
  Homepage (externer Link)
Date/Location: Thursday, 17.07.2014 15:00 Uhr in Building  28 / Pfälzer Platz, Room 027
Title:  The stress response mediated by translation factor eIF2-alpha phosphorylation controls splicing of tumor necrosis factor mRNA

 

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Talk

 

Name:      Dr. Timothy M. Palmer
  University of Glasgow, UK
Institute of Cardiovascular & Medical Sciences
  Homepage (external link)
Date/Location: Friday, 23.05.2014 14:30 Uhr in Building 28 / Pfälzer Platz, Room 027
Title:  Cavin‐1 and AMP‐activated protein kinase (AMPK) as new regulators of the JAK‐STAT pathway

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Talk

 

Name:      Prof. Dr. Gerhard Müller-Newen
  Institut für Biochemie und Molekularbiologie der RWTH Aachen
  Hompage (external link)
Date/Location: Tuesday, 12.11.2013 17:15 House 65/ZENIT I
Title:  Non-canonical aspects of Jak-STAT signaling

 

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Talk

 

Name:      Prof. Dr. Stephan Feller
  Cell Signalling Group, Weatherall Institute of Molecular Medicine,  Oxford, UK.
Institute of Molecular Medicine, Martin-Luther-University Halle-Wittenberg, ZAMED,  Halle, Germany
  Homepage Halle (external link)
Homepage Oxford (external link)
Date/Location: Wednesday, 02.10.2013 11:00 House 65/ZENIT I
Title:  Signal computation in large protein complexes downstream of receptor tyrosine kinases and strategies for their signal inhibition

 

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Last Modification: 01.08.2024 - Contact Person: Fred Schaper