News
Talk
| Name: | Dr. Michal Komorowski |
| Polish Academy of Science Institute of Fundamental Technological Research |
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| Homepage (external Link) | |
| Date/Location: | Tuesday, May 10th 2016, 5 pm, Building 28 / Room 27 |
| Title: | Information flow in signalling pathways |
| Abstact: | High throughput experimental approaches and the advances of computational capabilities continue to reshape modern biology. Thus, mathematical biology offers new possibilities for mathematicians and biologists to explore signal transduction, an important and highly complex aspect of cell biology. The molecular mechanisms how cells transduce biochemical signals are widely understood. Biochemical descriptions however failed to reveal how stimuli are translated into distinct responses. Signalling pathways are highly complex as they are functionally pleiotropic and biochemical reactions intrinsically stochastic. In the talk I will try to present how mathematical methods of information theory and probabilistic dynamical modelling can contribute to understanding of how information flows in signalling pathways.In particular, I will present developed analytical and computational tools required to improve our understanding how cellular signalling processes can derive a variety of distinct outputs from complex inputs. To overcome limitations of existing methods we have integrated advanced concepts of statistical inference with information theory and high content confocal imaging. The concepts have been applied to obtain new insights into mechanisms that govern dose dependent responses to type I interferons via STAT1 and STAT2 pathways as well as to TNF via NF-kB pathway. |
Interested guests are welcome!
Talk
| Name: | Prof. Dr. Karlheinz Friedrich |
| Medical School University of Jena Institute of Biochemistry II |
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| Homepage (external Link) | |
| Date/Location: | Wednesday, 09.03.2016 17:00 Building 16 / Room 154 |
| Title: | Thymic Stromal Lymphopoietin (TSLP) and its receptor: Signaling and medical aspects of an intriguing cytokine |
Interested guests are welcome!
Talk
| Name: | Prof. Dr. Serge Haan |
| Head of the Molecular Disease Mechanisms Group, Life Sciences Research Unit, University of Luxembourg | |
| Homepage (external link) | |
| Date/Location: | Thursday, 09.02.2015 17:00 Building 28 / Pfälzer Platz, Room 027 |
| Title: | The Jak/STAT/SOCS pathway in gastrointestinal malignancies |
Abstract: The Jak/STAT/SOCS pathway in gastrointestinal malignancies
Although the exact disease mechanisms are often not completely understood, the importance of Janus kinases, STAT factors and SOCS proteins in pathological processes is well established. In recent years, we were interested in the role of the Jak/STAT/SOCS signalling pathway in gastrointestinal diseases. One of our projects dealt with the potential role of SOCS proteins in colon cancer. By combining a meta-analysis with analyses of our own patient cohort we could identify SOCS2 and SOCS6 as potential biomarkers for colon cancer. Furthermore, we are interested in signalling mechanism initiated by mutated PDGFRa proteins. We are primarily interested in mutations occurring in the context of gastrointestinal stromal tumours (GIST) but we also extended our study to include an oncogenic fusion protein called FIP1L1-PDGFRa, which was identified in patients with chronic eosinophilic leukaemia. We found that the oncogenic mutants display skewed signalling properties if compared to the wild-type receptor. The observed unconventional signalling pattern includes the activation of STAT factors via a non-canonical activation mechanism.
Interested guests are welcome!
Talk
| Name: | PD. Dr. Heike Hermanns |
| Medizinische Klinik und Poliklinik II, Universität Würzburg | |
| Homepage (external link) | |
| Date/Location: | Thursday, 13.11.2014 17:00 Building 28 / Pfälzer Platz, Room 027 |
| Title: | Receptor endocytosis as fine-tuning mechanism to regulate IL-6-mediated inflammatory responses |
Interested guests are welcome!
Talk
| Name: | Prof. Dr. Raymond Kaempfer |
| Hebrew University of Jerusalem, School of Medicine, IMRIC Biochemistry and Molecular Biology, Israel | |
| Homepage (externer Link) | |
| Date/Location: | Thursday, 17.07.2014 15:00 Uhr in Building 28 / Pfälzer Platz, Room 027 |
| Title: | The stress response mediated by translation factor eIF2-alpha phosphorylation controls splicing of tumor necrosis factor mRNA |
Interested people are welcome!
Talk
| Name: | Dr. Timothy M. Palmer |
| University of Glasgow, UK Institute of Cardiovascular & Medical Sciences |
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| Homepage (external link) | |
| Date/Location: | Friday, 23.05.2014 14:30 Uhr in Building 28 / Pfälzer Platz, Room 027 |
| Title: | Cavin‐1 and AMP‐activated protein kinase (AMPK) as new regulators of the JAK‐STAT pathway |
Interested people are welcome!
Talk
| Name: | Prof. Dr. Stephan Feller |
| Cell Signalling Group, Weatherall Institute of Molecular Medicine, Oxford, UK. Institute of Molecular Medicine, Martin-Luther-University Halle-Wittenberg, ZAMED, Halle, Germany |
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| Homepage Halle (external link) Homepage Oxford (external link) |
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| Date/Location: | Wednesday, 02.10.2013 11:00 House 65/ZENIT I |
| Title: | Signal computation in large protein complexes downstream of receptor tyrosine kinases and strategies for their signal inhibition |
Interested people are welcome!
